The finger-mounted biomedical sensors provide a relatively small form factor for multiple measurements of cardiovascular and autonomic biomarkers on regular occasions. But it is important to know if the obtained biomarkers could be interpreted under conditions of changing optical coupling, contact pressure, and beat detection. In this paper, the analysis of the multimodal platform that allows synchronous recording of electrocardiography, red and infrared photoplethysmography, galvanic skin response, respiratory modulation, and motion was performed. The research question was how summary statistics of the protocol allow distinguishing between reliable stationary discrimination and less reliable ambulatory interpretation. Thus, the reliability-gated analysis was performed for the mean and standard deviation data presented in the paper. Hedges’ \(g\) was used to rank the standardized separation between the biomarker states, whereas a directional concordance index was calculated in order to determine the consistency of biomarker families under different operating conditions. The contrast of SUPINE to STAND allowed identifying the internally consistent stationary response with the total concordance of cardiac and pulse-arrival-time biomarkers, including large effects for LF/HF\(_{PAT}\), CE\(_{RR}\), CE\(_{PPir}\), LF/HF\(_{PPir}\), HR\(_{PPir}\), LF/HF\(_{RR}\), and HR\(_{RR}\). The contrast of SIT to WALK showed a well-maintained gross activation in terms of heart rate, galvanic skin response, and respiration. But the directional consistency of the biomarkers derived from the PPG became very poor (from 100.0% of stationary markers to 42.9% of ambulatory markers).